AustralieFrV1, Main, Exploration, bibRecord, 003138

Association of Alzheimer disease GWAS loci with MRI-markers of brain aging

Identifieur interne : 003138 ( Main/Exploration ); précédent : 003137; suivant : 003139

Association of Alzheimer disease GWAS loci with MRI-markers of brain aging

Auteurs : Ganesh Chauhan [France] ; Hieab H. H. Adams [Pays-Bas] ; Joshua C. Bis [États-Unis] ; Galit Weinstein [États-Unis] ; Lei Yu [États-Unis] ; Anna Maria Töglhofer [Autriche] ; Albert Vernon Smith [Islande] ; Sven Van Der Lee [Pays-Bas] ; Rebecca F. Gottesman [États-Unis] ; Russell Thomson [Australie] ; Jing Wang [États-Unis] ; Qiong Yang [États-Unis] ; Wiro J. Niessen [Pays-Bas] ; Oscar L. Lopez [États-Unis] ; James T. Becker [États-Unis] ; Thanh G. Phan [Australie] ; Richard J. Beare [Australie] ; Konstantinos Arfanakis [États-Unis] ; Debra Fleischman [États-Unis] ; Meike W. Vernooij [Pays-Bas] ; Bernard Mazoyer [France] ; Helena Schmidt [Autriche] ; Velandai Srikanth [Australie] ; Dave S. Knopman [États-Unis] ; Clifford R. Jack [États-Unis] ; Philippe Amouyel [France] ; Albert Hofman [Pays-Bas] ; Charlie Decarli [États-Unis] ; Christophe Tzourio [France] ; Cornelia M. Van Duijn [Pays-Bas] ; David A. Bennett [États-Unis] ; Reinhold Schmidt [Autriche] ; William T. Longstreth [États-Unis] ; Thomas H. Mosley [États-Unis] ; Myriam Fornage [États-Unis] ; Lenore J. Launer [États-Unis] ; Sudha Seshadri [États-Unis] ; M Arfan Ikram [Pays-Bas] ; Stephanie Debette [France, États-Unis]

Source :

Neurobiology of aging [ 0197-4580 ] ; 2015.

RBID : PMC:4391343

Descripteurs français

English descriptors

KwdEn :
- Aging (genetics), Aging (pathology), Alleles, Alzheimer Disease (genetics), Alzheimer Disease (pathology), Apolipoproteins E (genetics), Brain (pathology), Female, Genome-Wide Association Study, Hippocampus (pathology), Humans, Magnetic Resonance Imaging, Male, Organ Size (genetics), Polymorphism, Single Nucleotide, Risk, Sialic Acid Binding Ig-like Lectin 3 (genetics).
MESH :
- chemical , genetics : Apolipoproteins E, Sialic Acid Binding Ig-like Lectin 3.
- genetics : Aging, Alzheimer Disease, Organ Size.
- pathology : Aging, Alzheimer Disease, Brain, Hippocampus.
- Alleles, Female, Genome-Wide Association Study, Humans, Magnetic Resonance Imaging, Male, Polymorphism, Single Nucleotide, Risk.

Abstract

Whether novel risk variants of Alzheimer’s disease (AD) identified through genome-wide association studies (GWAS) also influence MRI-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume (ICV), total brain volume (TBV), hippocampal volume (HV), white matter hyperintensity (WMH) burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N=8,175–11,550). In single-SNP based tests, AD risk allele of APOE (rs2075650) was associated with smaller HV (p=0.0054) and CD33 (rs3865444) with smaller ICV (p=0.0058) In gene-based tests, there was associations of HLA-DRB1 with TBV (p=0.0006) and BIN1 with HV (p=0.00089). A weighted AD genetic risk score was associated with smaller HV (beta±SE=−0.047±0.013, p=0.00041), even after excluding the APOE locus (p=0.029). However, only association of AD genetic risk score with HV, including APOE, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in non-demented older community persons.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391343

DOI: 10.1016/j.neurobiolaging.2014.12.028
PubMed: 25670335
PubMed Central: 4391343

Affiliations:

Le document en format XML

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<author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J" last="Beare">Richard J. Beare</name>
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<author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name>
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<author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name>
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<author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
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<author><name sortKey="Knopman, Dave S" sort="Knopman, Dave S" uniqKey="Knopman D" first="Dave S" last="Knopman">Dave S. Knopman</name>
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<author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R" last="Jack">Clifford R. Jack</name>
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<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation wicri:level="3"><nlm:aff id="A25">Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
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<affiliation wicri:level="4"><nlm:aff id="A27">Université Lille 2, Lille, France</nlm:aff>
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<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Decarli, Charlie" sort="Decarli, Charlie" uniqKey="Decarli C" first="Charlie" last="Decarli">Charlie Decarli</name>
<affiliation wicri:level="2"><nlm:aff id="A28">Department of Neurology, University of California at Davis, Davis, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California at Davis, Davis, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation wicri:level="3"><nlm:aff id="A29">Department of Neuroepidemiology, INSERM U708, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neuroepidemiology, INSERM U708, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A30">Université Victor Segalen Bordeaux 2, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Victor Segalen Bordeaux 2</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A31">Netherlands Consortium for Healthy Aging, Leiden, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A32">Center for Medical Systems Biology, Leiden, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Center for Medical Systems Biology, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz</wicri:regionArea>
<wicri:noRegion>Medical University of Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Longstreth, William T" sort="Longstreth, William T" uniqKey="Longstreth W" first="William T" last="Longstreth">William T. Longstreth</name>
<affiliation wicri:level="4"><nlm:aff id="A34">Departments of Neurology and Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology and Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea>
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<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="2"><nlm:aff id="A35">Department of Medicine-Geriatrics/Gerontology, University of Mississippi Medical Center, Jackson, Mississippi, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine-Geriatrics/Gerontology, University of Mississippi Medical Center, Jackson, Mississippi</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="3"><nlm:aff id="A36">The Human Genetics Center and Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Human Genetics Center and Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston</wicri:regionArea>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">The Framingham Heart Study, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Framingham Heart Study, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A31">Netherlands Consortium for Healthy Aging, Leiden, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
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<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation wicri:level="1"><nlm:aff id="A1">INSERM U740 (Paris 7 University) and U708 (Bordeaux University), France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U740 (Paris 7 University) and U708 (Bordeaux University)</wicri:regionArea>
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<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A38">Department of Neurology, Lariboisière Hospital, Paris 7 University, DHU Neurovasc Paris Sorbonne, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, Lariboisière Hospital, Paris 7 University, DHU Neurovasc Paris Sorbonne, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A39">University of Versailles Saint-Quentin-en-Yvelines, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Versailles Saint-Quentin-en-Yvelines</wicri:regionArea>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Association of Alzheimer disease GWAS loci with MRI-markers of brain aging</title>
<author><name sortKey="Chauhan, Ganesh" sort="Chauhan, Ganesh" uniqKey="Chauhan G" first="Ganesh" last="Chauhan">Ganesh Chauhan</name>
<affiliation wicri:level="1"><nlm:aff id="A1">INSERM U740 (Paris 7 University) and U708 (Bordeaux University), France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U740 (Paris 7 University) and U708 (Bordeaux University)</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Adams, Hieab H H" sort="Adams, Hieab H H" uniqKey="Adams H" first="Hieab H. H." last="Adams">Hieab H. H. Adams</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name>
<affiliation wicri:level="4"><nlm:aff id="A4">Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Weinstein, Galit" sort="Weinstein, Galit" uniqKey="Weinstein G" first="Galit" last="Weinstein">Galit Weinstein</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">The Framingham Heart Study, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Framingham Heart Study, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Toglhofer, Anna Maria" sort="Toglhofer, Anna Maria" uniqKey="Toglhofer A" first="Anna Maria" last="Töglhofer">Anna Maria Töglhofer</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz</wicri:regionArea>
<wicri:noRegion>Medical University of Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Icelandic Heart Association, Kopavogur Capital Region, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Icelandic Heart Association, Kopavogur Capital Region</wicri:regionArea>
<wicri:noRegion>Kopavogur Capital Region</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A11">Department of Medicine, University of Iceland, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>Department of Medicine, University of Iceland, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Van Der Lee, Sven" sort="Van Der Lee, Sven" uniqKey="Van Der Lee S" first="Sven" last="Van Der Lee">Sven Van Der Lee</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Gottesman, Rebecca F" sort="Gottesman, Rebecca F" uniqKey="Gottesman R" first="Rebecca F" last="Gottesman">Rebecca F. Gottesman</name>
<affiliation wicri:level="3"><nlm:aff id="A12">Department of Neurology, Johns Hopkins School of Medicine, Baltimore, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Johns Hopkins School of Medicine, Baltimore</wicri:regionArea>
<placeName><settlement type="city">Baltimore</settlement>
<region type="state">Maryland</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A13">Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore</wicri:regionArea>
<placeName><settlement type="city">Baltimore</settlement>
<region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name>
<affiliation wicri:level="1"><nlm:aff id="A14">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania</wicri:regionArea>
<wicri:noRegion>Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name>
<affiliation wicri:level="2"><nlm:aff id="A6">The Framingham Heart Study, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Framingham Heart Study, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
<affiliation wicri:level="2"><nlm:aff id="A6">The Framingham Heart Study, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Framingham Heart Study, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A15">Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A17">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T" last="Becker">James T. Becker</name>
<affiliation wicri:level="2"><nlm:aff id="A16">Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A17">Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A18">Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania</wicri:regionArea>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G" last="Phan">Thanh G. Phan</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J" last="Beare">Richard J. Beare</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A20">Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Parkville, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Developmental Imaging Group, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Parkville, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A21">Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Biomedical Engineering, Illinois Institute of Technology, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<affiliation wicri:level="4"><nlm:aff id="A22">CNRS-CEA UMR5296, Université Bordeaux Segalen, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>CNRS-CEA UMR5296, Université Bordeaux Segalen, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
<settlement type="city">Bordeaux</settlement>
</placeName>
<orgName type="university">Université Bordeaux II</orgName>
</affiliation>
</author>
<author><name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="A9">Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz</wicri:regionArea>
<wicri:noRegion>Medical University of Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name>
<affiliation wicri:level="1"><nlm:aff id="A19">Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Stroke and Ageing Research Centre, Southern Clinical School, Department of Medicine, Monash University, Melbourne, Victoria</wicri:regionArea>
<wicri:noRegion>Victoria</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A14">Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Menzies Research Institute Tasmania, University of Tasmania, Hobart, Tasmania</wicri:regionArea>
<wicri:noRegion>Tasmania</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Knopman, Dave S" sort="Knopman, Dave S" uniqKey="Knopman D" first="Dave S" last="Knopman">Dave S. Knopman</name>
<affiliation wicri:level="2"><nlm:aff id="A23">Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Mayo Clinic College of Medicine, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R" last="Jack">Clifford R. Jack</name>
<affiliation wicri:level="2"><nlm:aff id="A24">Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Radiology, Mayo Clinic College of Medicine, Rochester, MN</wicri:regionArea>
<placeName><region type="state">Minnesota</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<affiliation wicri:level="3"><nlm:aff id="A25">Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Epidemiology and Public Health, Pasteur Institute of Lille, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A26">INSERM, U744, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM, U744, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="4"><nlm:aff id="A27">Université Lille 2, Lille, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Lille 2, Lille</wicri:regionArea>
<placeName><region type="region">Hauts-de-France</region>
<region type="old region">Nord-Pas-de-Calais</region>
<settlement type="city">Lille</settlement>
<settlement type="city">Lille</settlement>
</placeName>
<orgName type="university">Université Lille 2</orgName>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Decarli, Charlie" sort="Decarli, Charlie" uniqKey="Decarli C" first="Charlie" last="Decarli">Charlie Decarli</name>
<affiliation wicri:level="2"><nlm:aff id="A28">Department of Neurology, University of California at Davis, Davis, California, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, University of California at Davis, Davis, California</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<affiliation wicri:level="3"><nlm:aff id="A29">Department of Neuroepidemiology, INSERM U708, Bordeaux, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neuroepidemiology, INSERM U708, Bordeaux</wicri:regionArea>
<placeName><region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A30">Université Victor Segalen Bordeaux 2, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Université Victor Segalen Bordeaux 2</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A31">Netherlands Consortium for Healthy Aging, Leiden, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A32">Center for Medical Systems Biology, Leiden, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Center for Medical Systems Biology, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name>
<affiliation wicri:level="2"><nlm:aff id="A7">Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A8">Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurological Sciences, Rush University Medical Center, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
<affiliation wicri:level="1"><nlm:aff id="A33">Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Department of Neurology, Clinical Division of Neurogeriatrics, Medical University of Graz</wicri:regionArea>
<wicri:noRegion>Medical University of Graz</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Longstreth, William T" sort="Longstreth, William T" uniqKey="Longstreth W" first="William T" last="Longstreth">William T. Longstreth</name>
<affiliation wicri:level="4"><nlm:aff id="A34">Departments of Neurology and Epidemiology, University of Washington, Seattle, Washington, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Departments of Neurology and Epidemiology, University of Washington, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
<settlement type="city">Seattle</settlement>
</placeName>
<orgName type="university">Université de Washington</orgName>
</affiliation>
</author>
<author><name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name>
<affiliation wicri:level="2"><nlm:aff id="A35">Department of Medicine-Geriatrics/Gerontology, University of Mississippi Medical Center, Jackson, Mississippi, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Medicine-Geriatrics/Gerontology, University of Mississippi Medical Center, Jackson, Mississippi</wicri:regionArea>
<placeName><region type="state">État du Mississippi</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<affiliation wicri:level="3"><nlm:aff id="A36">The Human Genetics Center and Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Human Genetics Center and Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, Houston</wicri:regionArea>
<placeName><settlement type="city">Houston</settlement>
<region type="state">Texas</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name>
<affiliation wicri:level="2"><nlm:aff id="A37">Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Laboratory of Epidemiology and Population Sciences, Intramural Research Program, National Institute on Aging, National Institutes of Health, Bethesda, Maryland</wicri:regionArea>
<placeName><region type="state">Maryland</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A6">The Framingham Heart Study, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>The Framingham Heart Study, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name>
<affiliation wicri:level="3"><nlm:aff id="A2">Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A3">Department of Radiology, Erasmus Medical Center, Rotterdam, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Radiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A31">Netherlands Consortium for Healthy Aging, Leiden, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Netherlands Consortium for Healthy Aging, Leiden</wicri:regionArea>
<placeName><settlement type="city">Leyde</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<affiliation wicri:level="1"><nlm:aff id="A1">INSERM U740 (Paris 7 University) and U708 (Bordeaux University), France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>INSERM U740 (Paris 7 University) and U708 (Bordeaux University)</wicri:regionArea>
</affiliation>
<affiliation wicri:level="2"><nlm:aff id="A5">Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Neurology, Boston University School of Medicine, Boston, Massachusetts</wicri:regionArea>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A38">Department of Neurology, Lariboisière Hospital, Paris 7 University, DHU Neurovasc Paris Sorbonne, Paris, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>Department of Neurology, Lariboisière Hospital, Paris 7 University, DHU Neurovasc Paris Sorbonne, Paris</wicri:regionArea>
<placeName><region type="region">Île-de-France</region>
<region type="old region">Île-de-France</region>
<settlement type="city">Paris</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A39">University of Versailles Saint-Quentin-en-Yvelines, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>University of Versailles Saint-Quentin-en-Yvelines</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">Neurobiology of aging</title>
<idno type="ISSN">0197-4580</idno>
<idno type="eISSN">1558-1497</idno>
<imprint><date when="2015">2015</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging (genetics)</term>
<term>Aging (pathology)</term>
<term>Alleles</term>
<term>Alzheimer Disease (genetics)</term>
<term>Alzheimer Disease (pathology)</term>
<term>Apolipoproteins E (genetics)</term>
<term>Brain (pathology)</term>
<term>Female</term>
<term>Genome-Wide Association Study</term>
<term>Hippocampus (pathology)</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Organ Size (genetics)</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Risk</term>
<term>Sialic Acid Binding Ig-like Lectin 3 (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Allèles</term>
<term>Apolipoprotéines E (génétique)</term>
<term>Encéphale (anatomopathologie)</term>
<term>Femelle</term>
<term>Hippocampe (anatomopathologie)</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Lectine-3 de type Ig liant l'acide sialique (génétique)</term>
<term>Maladie d'Alzheimer (anatomopathologie)</term>
<term>Maladie d'Alzheimer (génétique)</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Risque</term>
<term>Taille d'organe (génétique)</term>
<term>Vieillissement (anatomopathologie)</term>
<term>Vieillissement (génétique)</term>
<term>Étude d'association pangénomique</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Apolipoproteins E</term>
<term>Sialic Acid Binding Ig-like Lectin 3</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Encéphale</term>
<term>Hippocampe</term>
<term>Maladie d'Alzheimer</term>
<term>Vieillissement</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Aging</term>
<term>Alzheimer Disease</term>
<term>Organ Size</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Apolipoprotéines E</term>
<term>Lectine-3 de type Ig liant l'acide sialique</term>
<term>Maladie d'Alzheimer</term>
<term>Taille d'organe</term>
<term>Vieillissement</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aging</term>
<term>Alzheimer Disease</term>
<term>Brain</term>
<term>Hippocampus</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Alleles</term>
<term>Female</term>
<term>Genome-Wide Association Study</term>
<term>Humans</term>
<term>Magnetic Resonance Imaging</term>
<term>Male</term>
<term>Polymorphism, Single Nucleotide</term>
<term>Risk</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Allèles</term>
<term>Femelle</term>
<term>Humains</term>
<term>Imagerie par résonance magnétique</term>
<term>Mâle</term>
<term>Polymorphisme de nucléotide simple</term>
<term>Risque</term>
<term>Étude d'association pangénomique</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P2">Whether novel risk variants of Alzheimer’s disease (AD) identified through genome-wide association studies (GWAS) also influence MRI-based intermediate phenotypes of AD in the general population is unclear. We studied association of 24 AD risk loci with intracranial volume (ICV), total brain volume (TBV), hippocampal volume (HV), white matter hyperintensity (WMH) burden, and brain infarcts in a meta-analysis of genetic association studies from large population-based samples (N=8,175–11,550). In single-SNP based tests, AD risk allele of <italic>APOE</italic>
 (rs2075650) was associated with smaller HV (p=0.0054) and <italic>CD33</italic>
 (rs3865444) with smaller ICV (p=0.0058) In gene-based tests, there was associations of <italic>HLA-DRB1</italic>
 with TBV (p=0.0006) and <italic>BIN1</italic>
 with HV (p=0.00089). A weighted AD genetic risk score was associated with smaller HV (beta±SE=−0.047±0.013, p=0.00041), even after excluding the <italic>APOE</italic>
 locus (p=0.029). However, only association of AD genetic risk score with HV, including <italic>APOE</italic>
, was significant after multiple testing correction (including number of independent phenotypes tested). These results suggest that novel AD genetic risk variants may contribute to structural brain aging in non-demented older community persons.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>Australie</li>
<li>Autriche</li>
<li>France</li>
<li>Islande</li>
<li>Pays-Bas</li>
<li>États-Unis</li>
</country>
<region><li>Aquitaine</li>
<li>Californie</li>
<li>Hauts-de-France</li>
<li>Hollande-Méridionale</li>
<li>Illinois</li>
<li>Maryland</li>
<li>Massachusetts</li>
<li>Minnesota</li>
<li>Nord-Pas-de-Calais</li>
<li>Nouvelle-Aquitaine</li>
<li>Pennsylvanie</li>
<li>Texas</li>
<li>Washington (État)</li>
<li>État du Mississippi</li>
<li>Île-de-France</li>
</region>
<settlement><li>Baltimore</li>
<li>Bordeaux</li>
<li>Houston</li>
<li>Leyde</li>
<li>Lille</li>
<li>Paris</li>
<li>Rotterdam</li>
<li>Seattle</li>
</settlement>
<orgName><li>Université Bordeaux II</li>
<li>Université Lille 2</li>
<li>Université de Washington</li>
</orgName>
</list>
<tree><country name="France"><noRegion><name sortKey="Chauhan, Ganesh" sort="Chauhan, Ganesh" uniqKey="Chauhan G" first="Ganesh" last="Chauhan">Ganesh Chauhan</name>
</noRegion>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<name sortKey="Amouyel, Philippe" sort="Amouyel, Philippe" uniqKey="Amouyel P" first="Philippe" last="Amouyel">Philippe Amouyel</name>
<name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<name sortKey="Mazoyer, Bernard" sort="Mazoyer, Bernard" uniqKey="Mazoyer B" first="Bernard" last="Mazoyer">Bernard Mazoyer</name>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
<name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name>
</country>
<country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Adams, Hieab H H" sort="Adams, Hieab H H" uniqKey="Adams H" first="Hieab H. H." last="Adams">Hieab H. H. Adams</name>
</region>
<name sortKey="Adams, Hieab H H" sort="Adams, Hieab H H" uniqKey="Adams H" first="Hieab H. H." last="Adams">Hieab H. H. Adams</name>
<name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name>
<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name>
<name sortKey="Ikram, M Arfan" sort="Ikram, M Arfan" uniqKey="Ikram M" first="M Arfan" last="Ikram">M Arfan Ikram</name>
<name sortKey="Niessen, Wiro J" sort="Niessen, Wiro J" uniqKey="Niessen W" first="Wiro J." last="Niessen">Wiro J. Niessen</name>
<name sortKey="Van Der Lee, Sven" sort="Van Der Lee, Sven" uniqKey="Van Der Lee S" first="Sven" last="Van Der Lee">Sven Van Der Lee</name>
<name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<name sortKey="Van Duijn, Cornelia M" sort="Van Duijn, Cornelia M" uniqKey="Van Duijn C" first="Cornelia M" last="Van Duijn">Cornelia M. Van Duijn</name>
<name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name>
<name sortKey="Vernooij, Meike W" sort="Vernooij, Meike W" uniqKey="Vernooij M" first="Meike W." last="Vernooij">Meike W. Vernooij</name>
</country>
<country name="États-Unis"><region name="Washington (État)"><name sortKey="Bis, Joshua C" sort="Bis, Joshua C" uniqKey="Bis J" first="Joshua C" last="Bis">Joshua C. Bis</name>
</region>
<name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name>
<name sortKey="Arfanakis, Konstantinos" sort="Arfanakis, Konstantinos" uniqKey="Arfanakis K" first="Konstantinos" last="Arfanakis">Konstantinos Arfanakis</name>
<name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T" last="Becker">James T. Becker</name>
<name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T" last="Becker">James T. Becker</name>
<name sortKey="Becker, James T" sort="Becker, James T" uniqKey="Becker J" first="James T" last="Becker">James T. Becker</name>
<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name>
<name sortKey="Bennett, David A" sort="Bennett, David A" uniqKey="Bennett D" first="David A" last="Bennett">David A. Bennett</name>
<name sortKey="Debette, Stephanie" sort="Debette, Stephanie" uniqKey="Debette S" first="Stephanie" last="Debette">Stephanie Debette</name>
<name sortKey="Decarli, Charlie" sort="Decarli, Charlie" uniqKey="Decarli C" first="Charlie" last="Decarli">Charlie Decarli</name>
<name sortKey="Fleischman, Debra" sort="Fleischman, Debra" uniqKey="Fleischman D" first="Debra" last="Fleischman">Debra Fleischman</name>
<name sortKey="Fornage, Myriam" sort="Fornage, Myriam" uniqKey="Fornage M" first="Myriam" last="Fornage">Myriam Fornage</name>
<name sortKey="Gottesman, Rebecca F" sort="Gottesman, Rebecca F" uniqKey="Gottesman R" first="Rebecca F" last="Gottesman">Rebecca F. Gottesman</name>
<name sortKey="Gottesman, Rebecca F" sort="Gottesman, Rebecca F" uniqKey="Gottesman R" first="Rebecca F" last="Gottesman">Rebecca F. Gottesman</name>
<name sortKey="Jack, Clifford R" sort="Jack, Clifford R" uniqKey="Jack C" first="Clifford R" last="Jack">Clifford R. Jack</name>
<name sortKey="Knopman, Dave S" sort="Knopman, Dave S" uniqKey="Knopman D" first="Dave S" last="Knopman">Dave S. Knopman</name>
<name sortKey="Launer, Lenore J" sort="Launer, Lenore J" uniqKey="Launer L" first="Lenore J" last="Launer">Lenore J. Launer</name>
<name sortKey="Longstreth, William T" sort="Longstreth, William T" uniqKey="Longstreth W" first="William T" last="Longstreth">William T. Longstreth</name>
<name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name>
<name sortKey="Lopez, Oscar L" sort="Lopez, Oscar L" uniqKey="Lopez O" first="Oscar L" last="Lopez">Oscar L. Lopez</name>
<name sortKey="Mosley, Thomas H" sort="Mosley, Thomas H" uniqKey="Mosley T" first="Thomas H" last="Mosley">Thomas H. Mosley</name>
<name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<name sortKey="Seshadri, Sudha" sort="Seshadri, Sudha" uniqKey="Seshadri S" first="Sudha" last="Seshadri">Sudha Seshadri</name>
<name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name>
<name sortKey="Wang, Jing" sort="Wang, Jing" uniqKey="Wang J" first="Jing" last="Wang">Jing Wang</name>
<name sortKey="Weinstein, Galit" sort="Weinstein, Galit" uniqKey="Weinstein G" first="Galit" last="Weinstein">Galit Weinstein</name>
<name sortKey="Weinstein, Galit" sort="Weinstein, Galit" uniqKey="Weinstein G" first="Galit" last="Weinstein">Galit Weinstein</name>
<name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
<name sortKey="Yang, Qiong" sort="Yang, Qiong" uniqKey="Yang Q" first="Qiong" last="Yang">Qiong Yang</name>
<name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name>
<name sortKey="Yu, Lei" sort="Yu, Lei" uniqKey="Yu L" first="Lei" last="Yu">Lei Yu</name>
</country>
<country name="Autriche"><noRegion><name sortKey="Toglhofer, Anna Maria" sort="Toglhofer, Anna Maria" uniqKey="Toglhofer A" first="Anna Maria" last="Töglhofer">Anna Maria Töglhofer</name>
</noRegion>
<name sortKey="Schmidt, Helena" sort="Schmidt, Helena" uniqKey="Schmidt H" first="Helena" last="Schmidt">Helena Schmidt</name>
<name sortKey="Schmidt, Reinhold" sort="Schmidt, Reinhold" uniqKey="Schmidt R" first="Reinhold" last="Schmidt">Reinhold Schmidt</name>
</country>
<country name="Islande"><noRegion><name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name>
</noRegion>
<name sortKey="Smith, Albert Vernon" sort="Smith, Albert Vernon" uniqKey="Smith A" first="Albert Vernon" last="Smith">Albert Vernon Smith</name>
</country>
<country name="Australie"><noRegion><name sortKey="Thomson, Russell" sort="Thomson, Russell" uniqKey="Thomson R" first="Russell" last="Thomson">Russell Thomson</name>
</noRegion>
<name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J" last="Beare">Richard J. Beare</name>
<name sortKey="Beare, Richard J" sort="Beare, Richard J" uniqKey="Beare R" first="Richard J" last="Beare">Richard J. Beare</name>
<name sortKey="Phan, Thanh G" sort="Phan, Thanh G" uniqKey="Phan T" first="Thanh G" last="Phan">Thanh G. Phan</name>
<name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name>
<name sortKey="Srikanth, Velandai" sort="Srikanth, Velandai" uniqKey="Srikanth V" first="Velandai" last="Srikanth">Velandai Srikanth</name>
</country>
</tree>
</affiliations>
</record>

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Serveur d'exploration sur les relations entre la France et l'Australie

Association of Alzheimer disease GWAS loci with MRI-markers of brain aging

Association of Alzheimer disease GWAS loci with MRI-markers of brain aging

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